LEDGF/p75: revisão sobre relação com doenças e interação com o sistema imunológico
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Orechio, D., & Duarte, E. C. (2016). LEDGF/p75: revisão sobre relação com doenças e interação com o sistema imunológico. Acta Scientiae Biological Research, 1(1), 33–46. Recuperado de https://revistas.unasp.edu.br/acb/article/view/731

Resumo

Resumo: Autoanticorpos são frequentemente utilizados como marcadores de
doenças autoimunes. Através de métodos de detecção, em 1994 foi encontrado um novo padrão nuclear de fl uorescência, denominado Pontilhado Fino Denso (PFd/DFS70). Esse anticorpo mostrou-se reativo contra uma proteína correspondente ao fator de transcrição p75 e ao fator de crescimento derivado do cristalino, sendo denominada posteriormente de LEDGF/p75. Além de ser um autoantígeno em várias situações infl amatórias e estar envolvido em algumas doenças autoimunes e alguns tipos de cânceres, é também um fator de crescimento e protege as células contra a morte celular. O anti-LEDGF/p75 é um anticorpo encontrado com frequência em indivíduos de aspecto saudável, sem nenhuma injúria aparente. Durante a fase de integração do vírus HIV, existe uma importante interação do LEDGF/p75 com a proteína integrase, o que o torna alvo para terapia viral. Futuros estudos sobre a proteína LEDGF/p75 devem enfatizar todo o mecanismo de atuação tanto em processos celulares naturais como patológicos, a fi m de colaborar na elucidação da forma de atuação do sistema imunológico em humanos.

Palavras-chave: LEDGF/p75; Autoimunidade; PFd; HIV; Doenças infl amatórias
crônicas.


Abstract: Autoantibodies are frequently used as markers of autoimmune diseases. Th rough detection methods, in 1994 a new nuclear fl uorescence pattern was found, called nuclear dense fi ne speckled pattern (PFd/DFS70). This antibody, subsequently called LEDGF/p75, proved to be reactive against a protein corresponding to the transcription factor p75 and to the growth factor derived from the crystalline. It is also a growth factor, an autoantigen in various infl ammatory conditions, protects cells against cell death, and additionally is involved in some autoimmune diseases and certain types of cancers. Th e anti-LEDGF/p75 is an antibody oft en found in apparently healthy individuals. In the HIV virus integration stage, there is a signifi - cant interaction of the LEDGF/p75 with the integrase protein, making it a potential target for viral therapy. Future studies on the protein LEDGF/p75 should emphasize the mechanism of action in both natural and pathological cellular processes in order to help elucidating the behavior of the immune system in humans.


Keywords: LEDGF/p75; Autoimmunity; PFd; HIV; Chronic infl ammatory
diseases.

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Referências

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